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Cover Picture: Chemistry and Biology in the Biosynthesis and Action of Thyroid Hormones (Angew. Chem. Int. Ed. 27/2016)
Author(s) -
Mondal Santanu,
Raja Karuppusamy,
Schweizer Ulrich,
Mugesh Govindasamy
Publication year - 2016
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201604415
Subject(s) - hormone , thyroid , deiodinase , prohormone , medicine , endocrinology , lipid metabolism , biosynthesis , chemistry , metabolism , enzyme , biochemistry , biology , thyroid hormones
Hormones secreted by the thyroid gland play an important role in lipid, carbohydrate, and protein metabolism, neural development, as well as cardiovascular, renal, and brain functions. The prohormone l ‐thyroxine (T4) undergoes monodeiodination by deiodinase enzymes to produce the biologically active hormone T3. G. Mugesh and co‐workers describe in their Review on page 7606 ff. the biosynthesis, transport, metabolism, and mechanism of action of thyroid hormones, as well as thyroid‐related disorders.