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Cover Picture: Iridium‐Catalyzed Enantioselective Hydroalkynylation of Enamides for the Synthesis of Homopropargyl Amides (Angew. Chem. Int. Ed. 31/2016)
Author(s) -
Bai XiaoYan,
Wang ZiXuan,
Li BiJie
Publication year - 2016
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201604414
Subject(s) - stereocenter , iridium , enantioselective synthesis , amide , alkyne , chemistry , combinatorial chemistry , enantiomer , stereochemistry , catalysis , organic chemistry
An Iridium‐Catalyzed asymmetric hydroalkynylation of enamides occur regioselectively at the β position of an enamide. In their Communication on page 9007 ff., B.‐J. Li and co‐workers report a method for the straightforward synthesis of chiral homopropargyl amides with a stereocenter β to the amide. As illustrated in the cover image, enamide and alkyne undergo rapid union to form a chiral product.
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