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Cover Picture: Radiation Damage and Racemic Protein Crystallography Reveal the Unique Structure of the GASA/Snakin Protein Superfamily (Angew. Chem. Int. Ed. 28/2016)
Author(s) -
Yeung Ho,
Squire Christopher J.,
Yosaatmadja Yuliana,
Panjikar Santosh,
López Gemma,
Molina Antonio,
Baker Edward N.,
Harris Paul W. R.,
Brimble Margaret A.
Publication year - 2016
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201604250
Subject(s) - crystal structure , chemistry , crystallography , protein structure , protein crystallization , disulfide bond , squire , breakage , materials science , biochemistry , organic chemistry , crystallization , archaeology , composite material , history
The antimicrobial protein snakin‐1,… . … isolated from potatoes, displays a uniquely folded three‐dimensional structure held together by six disulfide bonds. In their Communication on page 7930 ff., M. A. Brimble, C. J. Squire, and co‐workers describe how they used a radiation‐damage‐induced phasing (RIP) method to solve the racemic crystal structure of the protein, exploiting specific X‐ray radiation induced breakage of an endogenous C−I bond.