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Palladium Catalysis Enables Benzylation of α,α‐Difluoroketone Enolates
Author(s) -
Yang MingHsiu,
Hunt Jordan R.,
Sharifi Niusha,
Altman Ryan A.
Publication year - 2016
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201604149
Subject(s) - palladium , catalysis , chemistry , organic chemistry , combinatorial chemistry
A palladium‐catalyzed decarboxylative benzylation reaction of α,α‐difluoroketone enolates is reported, in which the key C(α)−C(sp 3 ) bond is generated by reductive elimination from a palladium intermediate. The transformation provides convergent access to α‐benzyl‐α,α‐difluoroketone‐based products, and should be useful for accessing biological probes.