Inside Cover: Controlled Generation of Singlet Oxygen in Living Cells with Tunable Ratios of the Photochromic Switch in Metal–Organic Frameworks (Angew. Chem. Int. Ed. 25/2016) | Zendy

Park Jihye | Zendy; Jiang Qin | Zendy; Feng Dawei | Zendy; Zhou HongCai | Zendy

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Inside Cover: Controlled Generation of Singlet Oxygen in Living Cells with Tunable Ratios of the Photochromic Switch in Metal–Organic Frameworks (Angew. Chem. Int. Ed. 25/2016)

Author(s) -

Park Jihye,

Jiang Qin,

Feng Dawei,

Zhou HongCai

Publication year - 2016

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Reports

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.201604085

Subject(s) - photochromism , singlet oxygen , photodynamic therapy , metal organic framework , materials science , nanoparticle , photochemistry , cover (algebra) , nanotechnology , molecular switch , optoelectronics , chemistry , oxygen , molecule , organic chemistry , mechanical engineering , adsorption , engineering

Improved 1 O 2 generation for photodynamic therapy (PDT) is possible with a MOF nanoparticle formulation of a photosensitizing system and a molecular switch. As H.‐C. Zhou and co‐workers show in their Communication on page 7188 ff., in situ incorporation of multiple components in the MOF nanoparticles enables a tunable ratio between the photochromic switch and the sensitizer. Compared to a simple mixture of this dyad, the MOF formulation gives enhanced in vitro PDT efficacy with a superior control of 1 O 2 production.

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