Premium
Inside Cover: Controlled Generation of Singlet Oxygen in Living Cells with Tunable Ratios of the Photochromic Switch in Metal–Organic Frameworks (Angew. Chem. Int. Ed. 25/2016)
Author(s) -
Park Jihye,
Jiang Qin,
Feng Dawei,
Zhou HongCai
Publication year - 2016
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201604085
Subject(s) - photochromism , singlet oxygen , photodynamic therapy , metal organic framework , materials science , nanoparticle , photochemistry , cover (algebra) , nanotechnology , molecular switch , optoelectronics , chemistry , oxygen , molecule , organic chemistry , mechanical engineering , adsorption , engineering
Improved 1 O 2 generation for photodynamic therapy (PDT) is possible with a MOF nanoparticle formulation of a photosensitizing system and a molecular switch. As H.‐C. Zhou and co‐workers show in their Communication on page 7188 ff., in situ incorporation of multiple components in the MOF nanoparticles enables a tunable ratio between the photochromic switch and the sensitizer. Compared to a simple mixture of this dyad, the MOF formulation gives enhanced in vitro PDT efficacy with a superior control of 1 O 2 production.