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Safe and Selective Nitro Group Reductions Catalyzed by Sustainable and Recyclable Fe/ppm Pd Nanoparticles in Water at Room Temperature
Author(s) -
Feng Jie,
Handa Sachin,
Gallou Fabrice,
Lipshutz Bruce H.
Publication year - 2016
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201604026
Subject(s) - nitro , catalysis , chemistry , aqueous solution , nanoparticle , aqueous medium , combinatorial chemistry , ligand (biochemistry) , green chemistry , peg ratio , reducing agent , organic chemistry , nanotechnology , materials science , reaction mechanism , finance , economics , biochemistry , alkyl , receptor
As a result of a unique synergy between ligand‐free Fe/ppm Pd nanoparticles and PEG‐containing designer surfactants, a facile and selective reduction of nitro‐containing aromatics and heteroaromatics can be effected in water at room temperature in the presence of NaBH 4 . This new nanotechnology involves low catalyst loadings, is highly chemoselective, and tolerates a wide variety of functional groups. The process, which includes recycling of the entire aqueous medium, offers a general, environmentally responsible, and notably safe approach to highly valued reductions of nitro‐containing compounds.