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Back Cover: Heat‐Flow‐Driven Oligonucleotide Gelation Separates Single‐Base Differences (Angew. Chem. Int. Ed. 23/2016)
Author(s) -
Morasch Matthias,
Braun Dieter,
Mast Christof B.
Publication year - 2016
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201603779
Subject(s) - oligonucleotide , cover (algebra) , sequence (biology) , chemistry , base (topology) , dna , crystallography , thermodynamics , materials science , biochemistry , physics , mathematics , mechanical engineering , mathematical analysis , engineering
Enzyme‐free sequence selection is an essential process for the emergence of first life. In their Communication on page 6676 ff., C. B. Mast and co‐workers show how a ubiquitous heat flux across a pore separates different DNA sequences with single‐base resolution. The picture shows a postulated prebiotic scenario of how a dilute mix of different sequences is thermophoretically concentrated and demixed by their sequence‐selective gelation.