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Ruthenium‐Catalyzed Modular Synthesis of Cyclic Tertiary Amines from Lactams
Author(s) -
Westhues Stefan,
Meuresch Markus,
Klankermayer Jürgen
Publication year - 2016
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201603385
Subject(s) - ruthenium , catalysis , chemistry , reagent , combinatorial chemistry , yield (engineering) , selectivity , alcohol , hydrogen molecule , organic chemistry , hydrogen , materials science , metallurgy
Reported is the development of a novel catalytic cascade reaction facilitating the modular synthesis of cyclic tertiary amines from simple lactam substrates and secondary alcohols. Using a single molecular ruthenium‐triphos catalyst in the presence of molecular hydrogen enabled the versatile formation of various amines in high yield with excellent selectivity. Extending the reaction system to using an alcohol as the hydrogen transfer reagent allowed the reduction of lactams without the need for molecular hydrogen.