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Towards a DNA Nanoprocessor: Reusable Tile‐Integrated DNA Circuits
Author(s) -
Gerasimova Yulia V.,
Kolpashchikov Dmitry M.
Publication year - 2016
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201603265
Subject(s) - tile , dna , computer science , logic gate , nucleic acid , nanotechnology , integrated circuit , chip , computer architecture , engineering , electronic engineering , materials science , biology , genetics , telecommunications , operating system , composite material
Modern electronic microprocessors use semiconductor logic gates organized on a silicon chip to enable efficient inter‐gate communication. Here, arrays of communicating DNA logic gates integrated on a single DNA tile were designed and used to process nucleic acid inputs in a reusable format. Our results lay the foundation for the development of a DNA nanoprocessor, a small and biocompatible device capable of performing complex analyses of DNA and RNA inputs.