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Inside Back Cover: Generation and Reaction of Carbamoyl Anions in Flow: Applications in the Three‐Component Synthesis of Functionalized α‐Ketoamides (Angew. Chem. Int. Ed. 17/2016)
Author(s) -
Nagaki Aiichiro,
Takahashi Yusuke,
Yoshida Junichi
Publication year - 2016
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201602731
Subject(s) - microreactor , component (thermodynamics) , cover (algebra) , derivative (finance) , chemistry , combinatorial chemistry , int , flow (mathematics) , polymer chemistry , materials science , organic chemistry , computer science , thermodynamics , physics , catalysis , engineering , programming language , mechanical engineering , mechanics , financial economics , economics
A flow microreactor system was used for the generation and reaction of unstable carbamoyl anions, specifically carbamoyllithium compounds, which is practically impossible to achieve by using the conventional batch method. As described by J. Yoshida, A. Nagaki, and Y. Takahashi in their Communication on page 5327 ff., the method was applied to the three‐component synthesis of functionalized α‐ketoamides, including the biologically active triazine derivative GW356194.