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Electrochemical C−H/N−H Functionalization for the Synthesis of Highly Functionalized (Aza)indoles
Author(s) -
Hou ZhongWei,
Mao ZhongYi,
Zhao HuaiBo,
Melcamu Yared Yohannes,
Lu Xin,
Song Jinshuai,
Xu HaiChao
Publication year - 2016
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201602616
Subject(s) - surface modification , electrochemistry , combinatorial chemistry , chemistry , indole test , nanotechnology , organic chemistry , materials science , electrode
Indoles and azaindoles are among the most important heterocycles because of their prevalence in nature and their broad utility in pharmaceutical industry. Reported herein is an unprecedented noble‐metal‐ and oxidant‐free electrochemical method for the coupling of (hetero)arylamines with tethered alkynes to synthesize highly functionalized indoles, as well as the more challenging azaindoles.