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Continuous‐Flow Synthesis and Derivatization of Aziridines through Palladium‐Catalyzed C(sp 3 )−H Activation
Author(s) -
Zakrzewski Jacek,
Smalley Adam P.,
Kabeshov Mikhail A.,
Gaunt Matthew J.,
Lapkin Alexei A.
Publication year - 2016
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201602483
Subject(s) - aziridine , derivatization , palladium , catalysis , chemistry , continuous flow , combinatorial chemistry , ring (chemistry) , organic chemistry , physics , high performance liquid chromatography , mechanics
A continuous‐flow synthesis of aziridines by palladium‐catalyzed C(sp 3 )−H activation is described. The new flow reaction could be combined with an aziridine‐ring‐opening reaction to give highly functionalized aliphatic amines through a consecutive process. A predictive mechanistic model was developed and used to design the C−H activation flow process and illustrates an approach towards first‐principles design based on novel catalytic reactions.