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Controlled Generation of Singlet Oxygen in Living Cells with Tunable Ratios of the Photochromic Switch in Metal–Organic Frameworks
Author(s) -
Park Jihye,
Jiang Qin,
Feng Dawei,
Zhou HongCai
Publication year - 2016
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201602417
Subject(s) - photosensitizer , singlet oxygen , photodynamic therapy , photochromism , photochemistry , homogeneous , chemistry , metal organic framework , energy transfer , intermolecular force , singlet state , nanotechnology , molecule , materials science , oxygen , chemical physics , organic chemistry , adsorption , physics , nuclear physics , thermodynamics , excited state
Development of a photosensitizing system that can reversibly control the generation of singlet oxygen ( 1 O 2 ) is of great interest for photodynamic therapy (PDT). Recently several photosensitizer–photochromic‐switch dyads were reported as a potential means of the 1 O 2 control in PDT. However, the delivery of such a homogeneous molecular dyad as designed (e.g., optimal molar ratio) is extremely challenging in living systems. Herein we show a Zr‐MOF nanoplatform, demonstrating energy transfer‐based 1 O 2 controlled PDT. Our strategy allows for tuning the ratios between photosensitizer and the switch molecule, enabling maximum control of 1 O 2 generation. Meanwhile, the MOF provides proximal placement of the functional entities for efficient intermolecular energy transfer. As a result, the MOF nanoparticle formulation showed enhanced PDT efficacy with superior 1 O 2 control compared to that of homogeneous molecular analogues.