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Iron‐Catalyzed Regioselective Transfer Hydrogenative Couplings of Unactivated Aldehydes with Simple Alkenes
Author(s) -
Zheng YanLong,
Liu YanYao,
Wu YiMei,
Wang YinXia,
Lin YuTong,
Ye Mengchun
Publication year - 2016
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201602130
Subject(s) - regioselectivity , chemistry , catalysis , aryl , alkyl , hydride , organic chemistry , styrene , combinatorial chemistry , transfer hydrogenation , coupling (piping) , hydrogen , materials science , polymer , ruthenium , copolymer , metallurgy
An FeBr 3 ‐catalyzed reductive coupling of various aldehydes with alkenes that proceeds through a direct hydride transfer pathway has been developed. With i PrOH as the hydrogen donor under mild conditions, previously challenging coupling reactions of unactivated alkyl and aryl aldehydes with simple alkenes, such as styrene derivatives and α‐olefins, proceeded smoothly to furnish a diverse range of functionalized alcohols with complete linear regioselectivity.