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Inside Back Cover: A Smart Photosensitizer–Manganese Dioxide Nanosystem for Enhanced Photodynamic Therapy by Reducing Glutathione Levels in Cancer Cells (Angew. Chem. Int. Ed. 18/2016)
Author(s) -
Fan Huanhuan,
Yan Guobei,
Zhao Zilong,
Hu Xiaoxiao,
Zhang Wenhan,
Liu Hui,
Fu Xiaoyi,
Fu Ting,
Zhang XiaoBing,
Tan Weihong
Publication year - 2016
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201602071
Subject(s) - photosensitizer , singlet oxygen , glutathione , photodynamic therapy , chemistry , manganese , cancer cell , reactive oxygen species , cancer therapy , photochemistry , nanotechnology , cancer , oxygen , materials science , biochemistry , medicine , organic chemistry , enzyme
A smart photosensitizer–MnO 2 nanosystem has been developed to enhance photodynamic therapy by reducing glutathione (GSH) levels in cancer cells. In their Communication on page 5477 ff, W. Tan and co‐workers show that this nanosystem could deplete intracellular GSH and generate singlet oxygen in the presence of light irradiation, thus increasing its efficiency in killing cancer cells. The picture depicts the system in the form of a computer game.