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Back Cover: Compact, Polyvalent Mannose Quantum Dots as Sensitive, Ratiometric FRET Probes for Multivalent Protein–Ligand Interactions (Angew. Chem. Int. Ed. 15/2016)
Author(s) -
Guo Yuan,
Sakonsinsiri Chadamas,
Nehlmeier Inga,
Fascione Martin A.,
Zhang Haiyan,
Wang Weili,
Pöhlmann Stefan,
Turnbull W. Bruce,
Zhou Dejian
Publication year - 2016
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201602014
Subject(s) - quantum dot , chemistry , sign (mathematics) , ligand (biochemistry) , cover (algebra) , dc sign , mannose , conjugated system , nanotechnology , biophysics , receptor , biochemistry , materials science , biology , antigen , genetics , mechanical engineering , mathematical analysis , mathematics , organic chemistry , dendritic cell , engineering , polymer
Four bees, mimicking the four carbohydrate‐recognition domains (CDRs) in the HIV/Ebola receptor DC‐SIGN, are searching for “lollipops”, that is, polyvalent carbohydrate‐conjugated quantum dots (QDs). To succeed, they have to follow the right “SIGN”, fly in the same direction, and work together. In their Communication on page 4738 ff., Y. Guo, D. Zhou et al. report on the simultaneous binding of four CRDs in DC‐SIGN with a polyvalent QD to achieve high‐affinity binding.