Inside Cover: Esterase‐Sensitive Prodrugs with Tunable Release Rates and Direct Generation of Hydrogen Sulfide (Angew. Chem. Int. Ed. 14/2016) | Zendy

Zheng Yueqin | Zendy; Yu Bingchen | Zendy; Ji Kaili | Zendy; Pan Zhixiang | Zendy; Chittavong Vayou | Zendy; Wang Binghe | Zendy

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Inside Cover: Esterase‐Sensitive Prodrugs with Tunable Release Rates and Direct Generation of Hydrogen Sulfide (Angew. Chem. Int. Ed. 14/2016)

Author(s) -

Zheng Yueqin,

Yu Bingchen,

Ji Kaili,

Pan Zhixiang,

Chittavong Vayou,

Wang Binghe

Publication year - 2016

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Reports

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.201602011

Subject(s) - prodrug , nucleophile , hydrogen sulfide , chemistry , sulfide , esterase , cover (algebra) , int , hydrogen , combinatorial chemistry , medicinal chemistry , stereochemistry , organic chemistry , catalysis , enzyme , biochemistry , sulfur , computer science , mechanical engineering , operating system , engineering

A series of thioacids is described as hydrogen sulfide prodrugs by B. Wang et al. in their Communication on page 4514 ff. The release takes advantage of a “trimethyl lock”‐facilitated lactonization controlled by an esterase trigger that unmasks a hydroxy group as the attacking nucleophile. These hydrogen sulfide prodrugs are stable under physiological conditions and release H 2 S with tunable release rates by modifying the ester group.

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