Premium
Enantioselective Synthesis of Cyclobutylboronates via a Copper‐Catalyzed Desymmetrization Approach
Author(s) -
GuisánCeinos Manuel,
Parra Alejandro,
MartínHeras Víctor,
Tortosa Mariola
Publication year - 2016
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201601976
Subject(s) - desymmetrization , enantioselective synthesis , cyclobutanes , copper , catalysis , chemistry , organic chemistry , cycloaddition
Abstract The first catalytic enantioselective synthesis of cyclobutylboronates, by using a chiral copper(I) complex, is reported. A broad variety of cyclobutanes have been prepared with consistently high levels of diastereo‐ and enantiocontrol. Moreover, this method constitutes the first report of an enantioselective desymmetrization of meso‐cyclobutenes to prepare chiral cyclobutanes.