Hamamelitannin Analogues that Modulate Quorum Sensing as Potentiators of Antibiotics against  Staphylococcus aureus | Zendy

Vermote Arno | Zendy; Brackman Gilles | Zendy; Risseeuw Martijn D. P. | Zendy; Vanhoutte Bieke | Zendy; Cos Paul | Zendy; Van Hecke Kristof | Zendy; Breyne Koen | Zendy; Meyer Evelyne | Zendy; Coenye Tom | Zendy; Van Calenbergh Serge | Zendy

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Hamamelitannin Analogues that Modulate Quorum Sensing as Potentiators of Antibiotics against Staphylococcus aureus

Author(s) -

Vermote Arno,

Brackman Gilles,

Risseeuw Martijn D. P.,

Vanhoutte Bieke,

Cos Paul,

Van Hecke Kristof,

Breyne Koen,

Meyer Evelyne,

Coenye Tom,

Van Calenbergh Serge

Publication year - 2016

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.201601973

Subject(s) - potentiator , quorum sensing , staphylococcus aureus , antibiotics , antimicrobial , microbiology and biotechnology , cytotoxicity , caenorhabditis elegans , biology , in vitro , chemistry , bacteria , biofilm , pharmacology , biochemistry , genetics , gene

The modulation of bacterial communication to potentiate the effect of existing antimicrobial drugs is a promising alternative to the development of novel antibiotics. In the present study, we synthesized 58 analogues of hamamelitannin (HAM), a quorum sensing inhibitor and antimicrobial potentiator. These efforts resulted in the identification of an analogue that increases the susceptibility of Staphylococcus aureus towards antibiotics in vitro, in Caenorhabditis elegans , and in a mouse mammary gland infection model, without showing cytotoxicity.

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