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Hamamelitannin Analogues that Modulate Quorum Sensing as Potentiators of Antibiotics against Staphylococcus aureus
Author(s) -
Vermote Arno,
Brackman Gilles,
Risseeuw Martijn D. P.,
Vanhoutte Bieke,
Cos Paul,
Van Hecke Kristof,
Breyne Koen,
Meyer Evelyne,
Coenye Tom,
Van Calenbergh Serge
Publication year - 2016
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201601973
Subject(s) - potentiator , quorum sensing , staphylococcus aureus , antibiotics , antimicrobial , microbiology and biotechnology , cytotoxicity , caenorhabditis elegans , biology , in vitro , chemistry , bacteria , biofilm , pharmacology , biochemistry , genetics , gene
The modulation of bacterial communication to potentiate the effect of existing antimicrobial drugs is a promising alternative to the development of novel antibiotics. In the present study, we synthesized 58 analogues of hamamelitannin (HAM), a quorum sensing inhibitor and antimicrobial potentiator. These efforts resulted in the identification of an analogue that increases the susceptibility of Staphylococcus aureus towards antibiotics in vitro, in Caenorhabditis elegans , and in a mouse mammary gland infection model, without showing cytotoxicity.