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Back Cover: Enantioselective Cyanosilylation of Ketones with Lithium(I) Dicyanotrimethylsilicate(IV) Catalyzed by a Chiral Lithium(I) Phosphoryl Phenoxide (Angew. Chem. Int. Ed. 12/2016)
Author(s) -
Hatano Manabu,
Yamakawa Katsuya,
Kawai Tomoaki,
Horibe Takahiro,
Ishihara Kazuaki
Publication year - 2016
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201601600
Subject(s) - enantioselective synthesis , lithium (medication) , ketone , catalysis , chemistry , medicinal chemistry , organic chemistry , medicine , endocrinology
The catalytic enantioselective cyanosilylation of ketones with highly reactive lithium dicyanotrimethylsilicate involves two lithium centers and is represented by Mr. Fukusuke holding two Engi‐kumades (bamboo rakes). In their Communication on page 4021 ff., K. Ishihara and co‐workers report on an acid–base cooperative catalytic system, an ( R )‐BINOL‐derived lithium phosphoryl phenoxide aqua complex, which activates both the ketone and lithium dicyanotrimethylsilicate.