Premium
Generation and Reaction of Carbamoyl Anions in Flow: Applications in the Three‐Component Synthesis of Functionalized α‐Ketoamides
Author(s) -
Nagaki Aiichiro,
Takahashi Yusuke,
Yoshida Junichi
Publication year - 2016
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201601386
Subject(s) - reagent , microreactor , electrophile , component (thermodynamics) , chemistry , chloroformate , combinatorial chemistry , organic chemistry , catalysis , physics , thermodynamics
Using a flow microreactor system, carbamoyllithium compounds were successfully generated and used for reactions with electrophiles to give various amides, including α‐ketoamides. The present method could be applied to the three‐component synthesis of functionalized α‐ketoamides using a carbamoyllithium compound, methyl chloroformate, and a functionalized organolithium reagent.