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Remote Control of T Cell Activation Using Magnetic Janus Particles
Author(s) -
Lee Kwahun,
Yi Yi,
Yu Yan
Publication year - 2016
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201601211
Subject(s) - janus , janus particles , magnetic nanoparticles , magnetic field , nanotechnology , materials science , chemistry , physics , nanoparticle , quantum mechanics
We report a strategy for using magnetic Janus microparticles to control the stimulation of T cell signaling with single‐cell precision. To achieve this, we designed Janus particles that are magnetically responsive on one hemisphere and stimulatory to T cells on the other side. By manipulating the rotation and locomotion of Janus particles under an external magnetic field, we could control the orientation of the particle–cell recognition and thereby the initiation of T cell activation. This study demonstrates a step towards employing anisotropic material properties of Janus particles to control single‐cell activities without the need of complex magnetic manipulation devices.