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Direct Asymmetric Reductive Amination for the Synthesis of Chiral β‐Arylamines
Author(s) -
Huang Haizhou,
Liu Xiaoyan,
Zhou Le,
Chang Mingxin,
Zhang Xumu
Publication year - 2016
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201601025
Subject(s) - reductive amination , phosphoramidite , enantioselective synthesis , chemistry , combinatorial chemistry , denticity , amination , iridium , ligand (biochemistry) , reactivity (psychology) , catalysis , organic chemistry , asymmetric hydrogenation , reductive elimination , crystal structure , receptor , dna , medicine , biochemistry , alternative medicine , pathology , oligonucleotide
The highly efficient and direct asymmetric reductive amination of arylacetones catalyzed by an iridium complex for the preparation of enantiomerically pure β‐arylamines is described. The monodentate phosphoramidite ligand exhibits superb reactivity (TONs of up to 20 000) and enantioselectivity (up to 99 % ee ). Additives played important roles in this reductive coupling reaction.