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Molecularly Regulated Reversible DNA Polymerization
Author(s) -
Chen Niancao,
Shi Xuechen,
Wang Yong
Publication year - 2016
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201601008
Subject(s) - polymer , nucleic acid , polymerization , dna , chemistry , conjugated system , molecule , aqueous solution , combinatorial chemistry , small molecule , nanotechnology , biophysics , polymer chemistry , materials science , organic chemistry , biochemistry , biology
Natural polymers are synthesized and decomposed under physiological conditions. However, it is challenging to develop synthetic polymers whose formation and reversibility can be both controlled under physiological conditions. Here we show that both linear and branched DNA polymers can be synthesized via molecular hybridization in aqueous solutions, on the particle surface, and in the extracellular matrix (ECM) without the involvement of any harsh conditions. More importantly, these polymers can be effectively reversed to dissociate under the control of molecular triggers. Since nucleic acids can be conjugated with various molecules or materials, we anticipate that molecularly regulated reversible DNA polymerization holds potential for broad biological and biomedical applications.