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Cooperative Lewis Acid/Cp*Co III Catalyzed C−H Bond Activation for the Synthesis of Isoquinolin‐3‐ones
Author(s) -
Kim Ju Hyun,
Greßies Steffen,
Glorius Frank
Publication year - 2016
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201601003
Subject(s) - catalysis , diazo , chemistry , lewis acids and bases , medicinal chemistry , combinatorial chemistry , stereochemistry , organic chemistry
A facile route toward the synthesis of isoquinolin‐3‐ones through a cooperative B(C 6 F 5 ) 3 ‐ and Cp*Co III ‐catalyzed C−H bond activation of imines with diazo compounds is presented. The inclusion of a catalytic amount of B(C 6 F 5 ) 3 results in a highly efficient reaction, thus enabling unstable NH imines to serve as substrates.