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Accelerated Discovery in Photocatalysis using a Mechanism‐Based Screening Method
Author(s) -
Hopkinson Matthew N.,
GómezSuárez Adrián,
Teders Michael,
Sahoo Basudev,
Glorius Frank
Publication year - 2016
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201600995
Subject(s) - photocatalysis , mechanism (biology) , biochemical engineering , computer science , combinatorial chemistry , quenching (fluorescence) , reactivity (psychology) , substrate (aquarium) , chemistry , nanotechnology , catalysis , materials science , organic chemistry , biology , engineering , physics , medicine , ecology , alternative medicine , pathology , quantum mechanics , fluorescence
Herein, we report a conceptually novel mechanism‐based screening approach to accelerate discovery in photocatalysis. In contrast to most screening methods, which consider reactions as discrete entities, this approach instead focuses on a single constituent mechanistic step of a catalytic reaction. Using luminescence spectroscopy to investigate the key quenching step in photocatalytic reactions, an initial screen of 100 compounds led to the discovery of two promising substrate classes. Moreover, a second, more focused screen provided mechanistic insights useful in developing proof‐of‐concept reactions. Overall, this fast and straightforward approach both facilitated the discovery and aided the development of new light‐promoted reactions and suggests that mechanism‐based screening strategies could become useful tools in the hunt for new reactivity.