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Polyfunctional Lithium, Magnesium, and Zinc Alkenyl Reagents as Building Blocks for the Synthesis of Complex Heterocycles
Author(s) -
Shen ZhiLiang,
Dhayalan Vasudevan,
Benischke Andreas D.,
Greiner Robert,
Karaghiosoff Konstantin,
Mayer Peter,
Knochel Paul
Publication year - 2016
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201600961
Subject(s) - reagent , silylation , lithium (medication) , chemistry , magnesium , pyridine , zinc , combinatorial chemistry , organic chemistry , carbon fibers , medicinal chemistry , catalysis , materials science , composite number , medicine , composite material , endocrinology
New conjunctive β‐silylated organometallic reagents of Li, Mg, and Zn have been prepared and used for an expeditive construction of various polyfunctionalized 5‐, 6‐, and 7‐membered heterocycles, such as furans, pyrroles, quinolines, benzo[ b ]thieno‐[2,3‐ b ]pyridine, naphthyridines, fused pyrazoles, and 2,3‐dihydro‐benzo[ c ]azepines. The latent silyl group has been converted into various carbon–carbon bonds in most heterocycle types.