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Product‐Derived Bimetallic Palladium Complex Catalyzes Direct Carbonylation of Sulfonylazides
Author(s) -
Zhao Jin,
Li Zongyang,
Song Shaole,
Wang MingAn,
Fu Bin,
Zhang Zhenhua
Publication year - 2016
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201600887
Subject(s) - palladium , carbonylation , bimetallic strip , product (mathematics) , chemistry , catalysis , organic chemistry , mathematics , carbon monoxide , geometry
Abstract A novel product‐derived bimetallic palladium complex catalyzes a sulfonylazide‐transfer reaction with the σ‐donor/π‐acceptor ligand CO, and is advantageous given its broad substrate scope, high efficiency, and mild reaction conditions (atmospheric pressure of CO at room temperature). This methodology provides a new approach to sulfonylureas, which are present in both pharmaceuticals and agrochemicals. The synthesis of Glibenclamide on a gram scale further revealed the practical utility of this procedure. Mechanistically, the generation of a bridged bimetallic palladium species derived from the product sulfonylurea is disclosed as the crucial step for this catalytic cycle.