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One‐Pot Trimetallic Relay Catalysis: A Unified Approach for the Synthesis of β‐Carbolines and Other [ c ]‐Fused Pyridines
Author(s) -
Dhiman Seema,
Mishra Uttam K.,
Ramasastry S. S. V.
Publication year - 2016
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201600840
Subject(s) - relay , catalysis , combinatorial chemistry , chemistry , computer science , stereochemistry , organic chemistry , physics , power (physics) , quantum mechanics
A divergent strategy is presented for the synthesis of 1,3‐di‐ and 1,3,4‐trisubstituted β‐carbolines through an unprecedented one‐pot triple‐orthogonal‐metal relay catalysis, and 1,3‐disubstituted 4‐hydroxy‐β‐carbolines through a one‐pot bimetallic relay catalysis from readily accessible 3‐(2‐aminophenyl)‐5‐hexenyn‐3‐ols. These strategies were elaborated to enable the synthesis of benzofuro[2,3‐ c ]pyridines, benzothieno[2,3‐ c ]pyridines, and isoquinolines, which otherwise require multistep synthesis.