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H 2 ‐Fueled ATP Synthesis on an Electrode: Mimicking Cellular Respiration
Author(s) -
GutiérrezSanz Óscar,
Natale Paolo,
Márquez Ileana,
Marques Marta C.,
Zacarias Sonia,
Pita Marcos,
Pereira Inês A. C.,
LópezMontero Iván,
De Lacey Antonio L.,
Vélez Marisela
Publication year - 2016
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201600752
Subject(s) - atp synthase , atpase , electrode , electrochemistry , chemistry , electrochemical gradient , hydrogenase , respiration , chemiosmosis , enzyme , biochemistry , cellular respiration , adenosine triphosphate , biophysics , membrane , mitochondrion , biology , botany
ATP, the molecule used by living organisms to supply energy to many different metabolic processes, is synthesized mostly by the ATPase synthase using a proton or sodium gradient generated across a lipid membrane. We present evidence that a modified electrode surface integrating a NiFeSe hydrogenase and a F 1 F 0 ‐ATPase in a lipid membrane can couple the electrochemical oxidation of H 2 to the synthesis of ATP. This electrode‐assisted conversion of H 2 gas into ATP could serve to generate this biochemical fuel locally when required in biomedical devices or enzymatic synthesis of valuable products.