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Copper/Guanidine‐Catalyzed Asymmetric Alkynylation of Isatins
Author(s) -
Chen Quangang,
Tang Yu,
Huang Tianyu,
Liu Xiaohua,
Lin Lili,
Feng Xiaoming
Publication year - 2016
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201600711
Subject(s) - alkynylation , guanidine , bifunctional , catalysis , enantioselective synthesis , chemistry , aryl , combinatorial chemistry , organic chemistry , alkyl , isatin , copper
The highly enantioselective alkynylation of isatins, catalyzed by a bifunctional guanidine/CuI catalyst under mild reaction conditions, is described. The reaction is broad in scope with respect to alkyl/aryl‐substituted terminal alkynes and substituted isatins, thus affording bioactive propargylic alcohols in excellent yields and enantioselectivities.