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Nickel‐Catalyzed Carboxylation of Benzylic C−N Bonds with CO 2
Author(s) -
Moragas Toni,
Gaydou Morgane,
Martin Ruben
Publication year - 2016
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201600697
Subject(s) - carboxylation , electrophile , catalysis , chemistry , nickel , reductive elimination , combinatorial chemistry , double bond , medicinal chemistry , organic chemistry
Abstract A user‐friendly Ni‐catalyzed reductive carboxylation of benzylic C−N bonds with CO 2 is described. This procedure outperforms state‐of‐the‐art techniques for the carboxylation of benzyl electrophiles by avoiding commonly observed parasitic pathways, such as homodimerization or β‐hydride elimination, thus leading to new knowledge in cross‐electrophile reactions.