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Total Synthesis of Cryptocaryol A by Enantioselective Iridium‐Catalyzed Alcohol C−H Allylation
Author(s) -
Perez Felix,
Waldeck Andrew R.,
Krische Michael J.
Publication year - 2016
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201600591
Subject(s) - enantioselective synthesis , iridium , total synthesis , polyketide , alcohol , chemistry , natural product , catalysis , diol , stereochemistry , combinatorial chemistry , organic chemistry , enzyme , biosynthesis
The polyketide natural product cryptocaryol A is prepared in 8 steps via iridium catalyzed enantioselective diol double C−H allylation, which directly generates an acetate‐based triketide stereodiad. In 4 previously reported total syntheses, 17–28 steps were required.