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Heterogeneous Rhodium‐Catalyzed Aerobic Oxidative Dehydrogenative Cross‐Coupling: Nonsymmetrical Biaryl Amines
Author(s) -
Matsumoto Kenji,
Yoshida Masahiro,
Shindo Mitsuru
Publication year - 2016
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201600400
Subject(s) - catalysis , rhodium , chemistry , oxidative phosphorylation , aryl , combinatorial chemistry , oxidative coupling of methane , organic chemistry , biochemistry , alkyl
The first heterogeneously catalyzed oxidative dehydrogenative cross‐coupling of aryl amines is reported herein. 2‐Naphthylamine analogues were reacted with various electron‐rich arenes using a heterogeneous Rh/C catalyst under mild aerobic conditions, thus affording nonsymmetrical biaryl amines in excellent yields with high selectivities. This reaction provides a mild, operationally simple, and efficient approach for the synthesis of biaryls which are important to pharmaceutical and materials chemistry.