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Catalytic Enantioselective Assembly of Homoallylic Alcohols from Dienes, Aryldiazonium Salts, and Aldehydes
Author(s) -
Tao ZhongLin,
Adili Alafate,
Shen HongCheng,
Han ZhiYong,
Gong LiuZhu
Publication year - 2016
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201600148
Subject(s) - enantioselective synthesis , chemistry , catalysis , palladium , organic chemistry , aldehyde , combinatorial chemistry
Abstract A highly selective multicomponent carbonyl allylation reaction of 1,3‐butadienes, aryldiazonium tetrafluoroborates, and aldehydes has been established under the combined catalysis of palladium acetate and chiral anion phase transfer to render the favorable assembly of chiral Z ‐configured homoallylic alcohols in high yields and with excellent levels of enantioselectivity.