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Asymmetric Synthesis of Axinellamines A and B
Author(s) -
Ma Zhiqiang,
Wang Xiao,
Ma Yuyong,
Chen Chuo
Publication year - 2016
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201600007
Subject(s) - imidazole , sponge , pyrrole , chemistry , stereochemistry , broad spectrum , oxidative phosphorylation , combinatorial chemistry , organic chemistry , biology , biochemistry , botany
Axinellamines A and B are broad‐spectrum antibacterial pyrrole–imidazole alkaloids that have a complex polycyclic skeleton. A new asymmetric synthesis of these marine sponge metabolites is described herein, featuring an oxidative rearrangement and an anchimeric chlorination reaction.