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Frontispiece: Reversal of a Single Base‐Pair Step Controls Guanine Photo‐Oxidation by an Intercalating Ruthenium(II) Dipyridophenazine Complex
Author(s) -
Keane Páraic M.,
Poynton Fergus E.,
Hall James P.,
Sazanovich Igor V.,
Towrie Michael,
Gunnlaugsson Thorfinnur,
Quinn Susan J.,
Cardin Christine J.,
Kelly John M.
Publication year - 2015
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201582961
Subject(s) - guanine , ruthenium , intercalation (chemistry) , dna , base pair , chemistry , stereochemistry , base (topology) , photochemistry , biochemistry , nucleotide , catalysis , organic chemistry , mathematical analysis , mathematics , gene
DNA Photooxidation Small changes in DNA sequence can have major biological effects. P. M. Keane, C. J. Cardin, J. M. Kelly et al. show on page 8364 ff. that the reversal of a single base‐pair step has a dramatic effect on the guanine photooxidation by a DNA‐intercalating Ru II complex.