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Ligand‐Enabled Arylation of γ‐C−H Bonds
Author(s) -
Li Suhua,
Zhu RuYi,
Xiao KaiJiong,
Yu JinQuan
Publication year - 2016
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201512020
Subject(s) - ligand (biochemistry) , reactivity (psychology) , quinoline , chemistry , amino acid , aryl , catalysis , combinatorial chemistry , stereochemistry , medicinal chemistry , organic chemistry , receptor , biochemistry , medicine , alkyl , alternative medicine , pathology
Pd II ‐catalyzed arylation of γ‐C(sp 3 )−H bonds of aliphatic acid‐derived amides was developed by using quinoline‐based ligands. Various γ‐aryl‐α‐amino acids were prepared from natural amino acids using this method. The influence of ligand structure on reactivity was also systematically investigated.