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Direct Spectroscopic Evidence for an n→π* Interaction
Author(s) -
Singh Santosh K.,
Mishra Kamal K.,
Sharma Neha,
Das Aloke
Publication year - 2016
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201511925
Subject(s) - conformational isomerism , non covalent interactions , formate , counterintuitive , chemistry , biomolecule , computational chemistry , chemical physics , stereochemistry , molecule , hydrogen bond , physics , organic chemistry , biochemistry , quantum mechanics , catalysis
The n→π* interaction is an extremely weak but very important noncovalent interaction. Although this interaction is widely present in biomolecules and materials, its existence is counterintuitive and so has been debated extensively. Herein, we have reported direct spectroscopic evidence for an n→π* interaction for the first time by probing the carbonyl stretching frequency in phenyl formate using isolated gas‐phase IR spectroscopy. This result also demonstrates that the conformational preference for the cis conformer of phenyl formate compared to the trans conformer arises due to the presence of the n→π* interaction in the former. The direct proof reported herein for this controversial but important noncovalent interaction should stimulate further experimental and theoretical investigation on this intriguing research topic.