Premium
Anion Recognition and Induced Self‐Assembly of an α,γ‐Cyclic Peptide To Form Spherical Clusters
Author(s) -
RodríguezVázquez Nuria,
Amorín Manuel,
Alfonso Ignacio,
Granja Juan R.
Publication year - 2016
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201511857
Subject(s) - chemistry , peptide , chloride , ion , transmembrane protein , crystallography , amino acid , stereochemistry , organic chemistry , biochemistry , receptor
A cyclic octapeptide composed of hydroxy‐functionalized γ‐amino acids folds in a “V‐shaped” conformation that allows the selective recognition of anions such as chloride, nitrate, and carbonate. The process involves the simultaneous self‐assembly of six peptide subunits and the recognition of four anions to form a tetrahedral structure, in which the anions are located at the corners of the resulting structure. Each anion is coordinated to three different peptides. The structure was fully characterized by several techniques, including NMR spectroscopy and X‐ray diffraction, and the material was able to facilitate the transmembrane transport of chloride ions.