Oxidative Conversion of a Europium(II)‐Based  T  1  Agent into a Europium(III)‐Based paraCEST Agent that can be Detected In Vivo by Magnetic Resonance Imaging | Zendy

Funk Alexander M. | Zendy; Clavijo Jordan Veronica | Zendy; Sherry A. Dean | Zendy; Ratnakar S. James | Zendy; Kovacs Zoltan | Zendy

Premium

Oxidative Conversion of a Europium(II)‐Based T 1 Agent into a Europium(III)‐Based paraCEST Agent that can be Detected In Vivo by Magnetic Resonance Imaging

Author(s) -

Funk Alexander M.,

Clavijo Jordan Veronica,

Sherry A. Dean,

Ratnakar S. James,

Kovacs Zoltan

Publication year - 2016

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.201511649

Subject(s) - europium , chemistry , reagent , lanthanide , dota , in vivo , chelation , nuclear magnetic resonance , proton , inorganic chemistry , ion , organic chemistry , physics , quantum mechanics , microbiology and biotechnology , biology

The Eu II complex of 1,4,7,10‐tetraazacyclododecane‐1,4,7,10‐tetraacetic acid (DOTA) tetra(glycinate) has a higher reduction potential than most Eu II chelates reported to date. The reduced Eu II form acts as an efficient water proton T 1 relaxation reagent, while the Eu III form acts as a water‐based chemical exchange saturation transfer (CEST) agent. The complex has extremely fast water exchange rate. Oxidation to the corresponding Eu III complex yields a well‐defined signal from the paraCEST agent. The time course of oxidation was studied in vitro and in vivo by T 1 ‐weighted and CEST imaging.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research