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Silver‐Mediated Intermolecular 1,2‐Alkylarylation of Styrenes with α‐Carbonyl Alkyl Bromides and Indoles
Author(s) -
Ouyang XuanHui,
Song RenJie,
Hu Ming,
Yang Yuan,
Li JinHeng
Publication year - 2016
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201511624
Subject(s) - surface modification , intermolecular force , alkyl , chemistry , selectivity , alkylation , substrate (aquarium) , combinatorial chemistry , organic chemistry , medicinal chemistry , molecule , catalysis , oceanography , geology
A new iron‐facilitated silver‐mediated radical 1,2‐alkylarylation of styrenes with α‐carbonyl alkyl bromides and indoles is described, and two new C−C bonds were generated in a single step through a sequence of intermolecular C(sp 3 )−Br functionalization and C(sp 2 )−H functionalization across the alkenes. This method provides an efficient access to alkylated indoles with broad substrate scope and excellent selectivity.