Inside Cover: Whole‐Cell Biocatalysts for Stereoselective C−H Amination Reactions (Angew. Chem. Int. Ed. 4/2016) | Zendy

Both Peter | Zendy; Busch Hanna | Zendy; Kelly Paul P. | Zendy; Mutti Francesco G. | Zendy; Turner Nicholas J. | Zendy; Flitsch Sabine L. | Zendy

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Inside Cover: Whole‐Cell Biocatalysts for Stereoselective C−H Amination Reactions (Angew. Chem. Int. Ed. 4/2016)

Author(s) -

Both Peter,

Busch Hanna,

Kelly Paul P.,

Mutti Francesco G.,

Turner Nicholas J.,

Flitsch Sabine L.

Publication year - 2016

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Reports

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.201511414

Subject(s) - stereoselectivity , amination , chemistry , amine gas treating , combinatorial chemistry , cover (algebra) , organic chemistry , stereochemistry , catalysis , engineering , mechanical engineering

Enantiomerically pure chiral amines are ubiquitous chemical building blocks in bioactive pharmaceuticals. One of the most attractive strategies for their synthesis is the stereoselective installation of a chiral amine through formal C−H amination. In their Communication on page 1511 ff., S. Flitsch et al. report the construction and application of a multienzyme cascade in a single bacterial whole cell which is able to catalyze stereoselective benzylic aminations.

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