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Inside Cover: Whole‐Cell Biocatalysts for Stereoselective C−H Amination Reactions (Angew. Chem. Int. Ed. 4/2016)
Author(s) -
Both Peter,
Busch Hanna,
Kelly Paul P.,
Mutti Francesco G.,
Turner Nicholas J.,
Flitsch Sabine L.
Publication year - 2016
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201511414
Subject(s) - stereoselectivity , amination , chemistry , amine gas treating , combinatorial chemistry , cover (algebra) , organic chemistry , stereochemistry , catalysis , engineering , mechanical engineering
Enantiomerically pure chiral amines are ubiquitous chemical building blocks in bioactive pharmaceuticals. One of the most attractive strategies for their synthesis is the stereoselective installation of a chiral amine through formal C−H amination. In their Communication on page 1511 ff., S. Flitsch et al. report the construction and application of a multienzyme cascade in a single bacterial whole cell which is able to catalyze stereoselective benzylic aminations.