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Noninvasive Staging of Kidney Dysfunction Enabled by Renal‐Clearable Luminescent Gold Nanoparticles
Author(s) -
Yu Mengxiao,
Zhou Jiancheng,
Du Bujie,
Ning Xuhui,
Authement Craig,
Gandee Leah,
Kapur Payal,
Hsieh JerTsong,
Zheng Jie
Publication year - 2016
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201511148
Subject(s) - kidney , medicine , kidney disease , renal function , in vivo , pathology , nephropathy , biology , endocrinology , microbiology and biotechnology , diabetes mellitus
As a “silent killer”, kidney disease is often hardly detected at an early stage but can cause lethal kidney failure later on. Thus, a preclinical imaging technique that can readily differentiate between the stages of kidney dysfunction is highly desired for improving our fundamental understanding of kidney disease progression. Herein, we report that in vivo fluorescence imaging, enabled by renal‐clearable near‐infrared‐emitting gold nanoparticles, can noninvasively detect kidney dysfunction, report on the dysfunctional stages, and even reveal adaptive function in a mouse model of unilateral obstructive nephropathy, which cannot be diagnosed with routine kidney function markers. These results demonstrate that low‐cost fluorescence kidney functional imaging is highly sensitive and useful for the longitudinal, noninvasive monitoring of kidney dysfunction progression in preclinical research.