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Inside Back Cover: Resonance Energy Transfer Relates the Gas‐Phase Structure and Pharmacological Activity of Opioid Peptides (Angew. Chem. Int. Ed. 2/2016)
Author(s) -
Kopysov Vladimir,
Boyarkin Oleg V.
Publication year - 2016
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201511041
Subject(s) - resonance (particle physics) , chemistry , mass spectrometry , molecule , opioid , cover (algebra) , energy transfer , opioid peptide , phase (matter) , spectroscopy , gas phase , förster resonance energy transfer , stereochemistry , receptor , organic chemistry , biochemistry , chemical physics , physics , atomic physics , chromatography , mechanical engineering , quantum mechanics , engineering , fluorescence
The spacing between the two aromatic rings of the opioid peptides enkephalins determines the pharmacology of these pain‐relief drugs. In their Communication on page 689 ff., V. Kopysov and O. V. Boyarkin report on the use of resonance energy transfer, detected by a combination of cold‐ion spectroscopy and mass spectrometry, to estimate these distances in the gas phase. These distances appear to correlate with the pharmacological efficiencies of the studied drug molecule.