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Organo‐Iodine(III)‐Catalyzed Oxidative Phenol–Arene and Phenol–Phenol Cross‐Coupling Reaction
Author(s) -
Morimoto Koji,
Sakamoto Kazuma,
Ohshika Takao,
Dohi Toshifumi,
Kita Yasuyuki
Publication year - 2016
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201511007
Subject(s) - hypervalent molecule , phenol , regioselectivity , phenols , catalysis , chemistry , oxidative coupling of methane , iodine , coupling reaction , oxidative phosphorylation , functional group , reaction conditions , metal , organic chemistry , combinatorial chemistry , photochemistry , biochemistry , polymer
The direct oxidative coupling reaction has been an attractive tool for environmentally benign chemistry. Reported herein is that the hypervalent iodine catalyzed oxidative metal‐free cross‐coupling reaction of phenols can be achieved using Oxone as a terminal oxidant in 1,1,1,3,3,3‐hexafluoropropan‐2‐ol (HFIP). This method features a high efficiency and regioselectivity, as well as functional‐group tolerance under very mild reaction conditions without using metal catalysts.