Cationic Cobalt(III) Catalyzed Indole Synthesis: The Regioselective Intermolecular Cyclization of N‐Nitrosoanilines and Alkynes | Zendy

Liang Yujie | Zendy; Jiao Ning | Zendy

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Cationic Cobalt(III) Catalyzed Indole Synthesis: The Regioselective Intermolecular Cyclization of N‐Nitrosoanilines and Alkynes

Author(s) -

Liang Yujie,

Jiao Ning

Publication year - 2016

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.201511002

Subject(s) - regioselectivity , reactivity (psychology) , cationic polymerization , cobalt , catalysis , chemistry , indole test , intermolecular force , medicinal chemistry , stereochemistry , organic chemistry , molecule , alternative medicine , medicine , pathology

The unique regioselectivity and reactivity of cobalt(III) in the direct cyclization of N‐nitrosoanilines with alkynes for the expedient synthesis of N‐substituted indoles is demonstrated. In the presence of a cobalt(III) catalyst, high regioselectivity was observed when using unsymmetrical meta ‐substituted N‐nitrosoanilines. Moreover, internal alkynes bearing electron‐deficient groups, which are almost unreactive in the [Cp*Rh III ]‐catalyzed system, display good reactivity in this transformation.

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