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Multifunctional Antioxidants: Regenerable Radical‐Trapping and Hydroperoxide‐Decomposing Ebselenols
Author(s) -
Kumar Shailesh,
Yan Jiajie,
Poon Jiafei,
Singh Vijay P.,
Lu Xi,
Karlsson Ott Marjam,
Engman Lars,
Kumar Sangit
Publication year - 2016
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201510947
Subject(s) - ebselen , chemistry , reactive oxygen species , radical , antioxidant , reactive nitrogen species , peroxidase , glutathione , oxygen , enzyme , glutathione peroxidase , biochemistry , organic chemistry
Abstract Regenerable, multifunctional ebselenol antioxidants were prepared that could quench peroxyl radicals more efficiently than α‐tocopherol. These compounds act as better mimics of the glutathione peroxidase enzymes than ebselen. Production of reactive oxygen species (ROS) and reactive nitrogen species (RNS) in human mononuclear cells was considerably decreased upon exposure to the organoselenium compounds. At a concentration of 25 μ m , the ebselenol derivatives showed minimal toxicity in pre‐osteoblast MC3T3 cells.