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Cover Picture: Structures of Iridoid Synthase from Cantharanthus roseus with Bound NAD + , NADPH, or NAD + /10‐Oxogeranial: Reaction Mechanisms (Angew. Chem. Int. Ed. 51/2015)
Author(s) -
Hu Yumei,
Liu Weidong,
Malwal Satish R.,
Zheng Yingying,
Feng Xinxin,
Ko TzuPing,
Chen ChunChi,
Xu Zhongxia,
Liu Meixia,
Han Xu,
Gao Jian,
Oldfield Eric,
Guo ReyTing
Publication year - 2015
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201510890
Subject(s) - iridoid , stereochemistry , atp synthase , nad+ kinase , biosynthesis , chemistry , terpene , glycoside , substrate (aquarium) , enzyme , biochemistry , biology , ecology
The unconventional terpene synthase iridoid synthase (IRIS) produces nepetalactol, a precursor for drugs such as vincristine. In their Communication on page 15478 ff., E. Oldfield, R.‐T. Guo, and co‐workers present the structures of IRIS from Cantharanthus roseus in complex with NADP and the substrate 10‐oxogeranial. The structures show how nepetalactol and the byproduct oxo‐citronellal are formed and provide insight into the biosynthesis of iridoids and cardiac glycosides.