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Framework Cationization by Preemptive Coordination of Open Metal Sites for Anion‐Exchange Encapsulation of Nucleotides and Coenzymes
Author(s) -
Zhao Xiang,
Mao Chengyu,
Luong Karen Tu,
Lin Qipu,
Zhai QuanGuo,
Feng Pingyun,
Bu Xianhui
Publication year - 2016
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201510812
Subject(s) - cofactor , chemistry , nucleotide , coordination complex , metal , stereochemistry , combinatorial chemistry , biochemistry , organic chemistry , gene , enzyme
Cationic frameworks can selectively trap anions through ion exchange, and have applications in ion chromatography and drug delivery. However, cationic frameworks are much rarer than anionic or neutral ones. Herein, we propose a concept, preemptive coordination (PC), for targeting positively charged metal–organic frameworks (P‐MOFs). PC refers to proactive blocking of metal coordination sites to preclude their occupation by neutralizing ligands such as OH − . We use 20 MOFs to show that this PC concept is an effective approach for developing P‐MOFs whose high stability, porosity, and anion‐exchange capability allow immobilization of anionic nucleotides and coenzymes, in addition to charge‐ and size‐selective capture or separation of organic dyes. The CO 2 and C 2 H 2 uptake capacity of 117.9 cm 3 g −1 and 148.5 cm 3 g −1 , respectively, at 273 K and 1 atm, is exceptionally high among cationic framework materials.